CYCLOASTRAGENOL 60 CÁPSULAS 

Anti-aging breakthrough

Precio recomendado: 69,95 €

Marca: Hydrapharm

 

Cycloastragenol is one of the most exciting ingredients when it comes to natural support for healthy aging.

Cycloastragenol should be dosed daily all year-round on a long term basis to experience the benefits. Discontinuing usage is not recommended once a user embarks on an anti-aging regimen based around this compound.

Both men and women seeking to age with confidence.

Anti-aging breakthrough

Age with confidence

Look after your general wellbeing

Keep in control of your energy and mood

Sleep deeper than ever

The most bioactive ingredient in Astragalus root extract, a herb which has a great track record. Astragalus itself has relatively poor solubility and low bioavailability, and with its benefits being derived from cycloastragenol anyway, it explains why cycloastragenol supplements are booming lately with its anti-aging properties with various brand name forms such as CA-98 (98% cycloastragenol content) and TA-65 becoming popular. However, the Hydrapharm Cycloastragenol supplement goes further still in being dosed at over 99% cycloastragenol content making it the best cycloastragenol supplement available in the UK today.

How Does Cycloastragenol Work?

Cycloastragenol works by inhibiting reactive oxygen species generation and attenuates endoplasmic reticulum stress (2). Reactive oxygen species can have a deleterious effect DNA and RNA and plays a negative role in the physiology of aging. Interestingly, the outer face of the rough endoplasmic reticulum is studded with ribosomes that are the sites for protein synthesis.

Cycloastragenol specifically stops the inflammatory activation of TXNIP/NLRP3. Inflammatory activation leads to mitochondrial cell death in endothelial cells, but cycloastragenol has the capacity to restore the loss of the mitochondrial membrane potential by preventing caspase-3 activity, resulting in the protection of cells from endoplasmic reticulum stress induced apoptosis. This study found cycloastragenol to be effective in regulating endothelial homeostasis by ameliorating endothelial dysfunction specifically by inhibiting inflammation and reducing cell apoptosis (1).

Cycloastragenol and Telomeres

Telomeres consist of repetitive non-coding DNA sequences located at chromosomes. They play a protective role in the chromosome ends along with shelterin complex. The shelterin complex consists of six telomere associated proteins and allows cells in the body to distinguish telomeres from DNA damage sites. Without this, unprotected teleomeres provoke a DNA damage response (3).

Telomere shortening occurs due to the end replication problem in DNA replication – the DNA strand shortens with each cell division, since the DNA polymerase can’t completely replicate the whole strand. As well as this problem, reactive oxygen species and other environmental stress factors lead to telomere damage and increase erosion of the telomere.

Cycloastragenol has been shown to activate telomerease in T lymphocytes, helping to inhibit telomere shortening, proliferative potential and enhance functional response. This has made it an interesting area of research in cancer treatment, aging, psychiatric disorders such as depression, atherosclerosis, skin diseases and regenerative medicine (4, 5). Although the research on cycloastragenol is in its early days, it is being proposed as a potential therapeutic answer for anti-aging and telomerase-dependent disease treatments.

Conclusion

Cycloastragenol provides a potent antioxidant that helps to reduce inflammation. This, along with its ability to provide liver protective properties and reduce the activity of reactive oxygen species, makes it relevant to individuals who are constantly engaged in strenuous exercise.

It’s ability to reduce endothelium stress and inhibit telemorase shortening has made it a potential therapeutic solution for a number of diseases such as cancer treatment and regenerative medicine.

It may be cliché, but further research in human studies is needed on cycloastragenol to determine the specific effects of its wide ranging benefits in specific diseases - the pharmaceutical companies seem to be dragging their feet with further research on cycloastragenol, but at Predator Nutrition we feel we didn’t want you to miss out on this wide-ranging beneficial ingredient.

1. ZHANG Shi-di;LU Jun-kun;YAN Ji-zhong;ZHANG Hui;Zhejiang. Research progress of the preparation technology and pharmacological effect of cycloastragenol. Chinese Journal of New Drugs. 2016-16.

2.YanZhao, QiangLi, WenjunZhao, JiaLi, YanSun,, KangLiu, BaolinLiu, NingZhang. Astragaloside IV andcycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium. Journal of EthnopharmacologyVolume 169, 1 July 2015, Pages 210-218.

3. Kathrin Jäger, Michael Walter. Therapeutic Targeting of Telomerase. Genes 2016, 7(7), 39; doi:10.3390/genes7070039.

4. Ip F.C.F, Ng Y.P, An H.J, Dai Y, Pang H.H, Hu Y.Q, Chin A.C, Harley C.B, Wong Y.H, Ip N.Y. Neurosignals. 2014, Vol.22, No. 1.

5. Weiss R. Evaluation of a Novel Anti-aging Topical Formulation Containing Cycloastragenol, Growth Factors, Peptides and Antioxidants. Jan Marini Skin Research.

Información nutricional: 

Por dosis de 1 cápsula: 

Cicloastragenol: 5 mg*

* Valor diario no establecido

Ingredientes: 

Cicloastragenol. 

Otros ingredientes: Celulosa microcristalina, Gelatina (cápsula), Harina de arroz, Estearato de magnesio

Modo de empleo: 

18-49 años: tomar 1-2 cápsulas al día con el estómago vacío.

50-69 años: tomar 2-3 cápsulas al día con el estómago vacío.

70+ años: tomar 5 cápsulas al día con el estómago vacío.

Presentación:

Envase de 60 cápsulas.

 

Atención:

Los productos aquí mostrados son suplementos nutricionales según lo establece la Directiva Europea 2002/46/CE sobre complementos alimenticios y todos ellos pueden ser vendidos legalmente en todos los países de la Comunidad Europea, por los artículos 28, 29 y 30 del tratado de la Comunidad Europea y por los artículos 1 a 4 de la Decisión del Parlamento Europeo número 3052/95/CE. Los suplementos alimenticios no tratan de sustituir una dieta equilibrada y variada, únicamente se presentan con el fin de complementar la ingesta de nutrientes de una dieta normal. Tampoco tratan, previenen, diagnostican o curan ninguna enfermedad, hechos atribuibles a los medicamentos, según define la Directiva Europea 2004/27/CE, de 31 de marzo, del Consejo y del Parlamento Europeo sobre medicamentos. Se reserva el derecho de enviar productos a países donde el país de destino no permita. Los productos no deben utilizarse como sustituto de una dieta o medicación y deben estar fuera del alcance de los niños. El consumo de los productos debe ser controlado por un profesional, ante cualquier duda, siempre consulte a su médico.